MGP Database

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MGP003691

UniProt Annotations

Entry Information
Gene Nametumor necrosis factor receptor superfamily, member 10b
Protein EntryTR10B_HUMAN
UniProt IDO14763
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=Long; Synonyms=TRICK2B; IsoId=O14763-1; Sequence=Displayed; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=O14763-3; Sequence=VSP_039125; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=Short; Synonyms=TRICK2A; IsoId=O14763-2; Sequence=VSP_006490; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.;
DiseaseSquamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Note=The disease may be caused by mutations affecting the gene represented in this entry.
FunctionReceptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis. {ECO:0000269|PubMed:15322075}.
InductionBy ER stress. Regulated by p53/TP53. {ECO:0000269|PubMed:15322075}.
InteractionP50591:TNFSF10; NbExp=21; IntAct=EBI-518882, EBI-495373;
SimilarityContains 1 death domain. {ECO:0000255|PROSITE- ProRule:PRU00064}.
SimilarityContains 3 TNFR-Cys repeats. {ECO:0000255|PROSITE- ProRule:PRU00206}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHomotrimer. Can interact with TRADD and RIPK1. Interacts with HCMV protein UL141; this interaction prevents TNFRSF10B cell surface expression. Two TNFRSF10B monomers interact with a UL141 homodimer. {ECO:0000269|PubMed:23498957, ECO:0000269|PubMed:23555243}.
Tissue SpecificityWidely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
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