MGP Database

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MGP003694

UniProt Annotations

Entry Information
Gene Namesuccinate-CoA ligase, GDP-forming, beta subunit
Protein EntrySUCB2_HUMAN
UniProt IDQ96I99
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96I99-1; Sequence=Displayed; Name=2; IsoId=Q96I99-2; Sequence=VSP_042013; Note=No experimental confirmation available.;
Catalytic ActivityGTP + succinate + CoA = GDP + phosphate + succinyl-CoA.
FunctionCatalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA. {ECO:0000250}.
PathwayCarbohydrate metabolism; tricarboxylic acid cycle.
Sequence CautionSequence=AAH07716.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH47024.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH47024.1; Type=Erroneous termination; Positions=31; Note=Translated as Gln.; Evidence={ECO:0000305};
SimilarityBelongs to the succinate/malate CoA ligase beta subunit family. {ECO:0000305}.
SimilarityContains 1 ATP-grasp domain. {ECO:0000305}.
Subcellular LocationMitochondrion.
SubunitHeterodimer of an alpha and a beta subunit.
Tissue SpecificityMainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and colon, and in low amounts in lung, brain, prostate, testis and ovary. {ECO:0000269|PubMed:9765291}.
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