Log in / Register

MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

MGP003703

UniProt Annotations

Entry Information

Gene Name	Sin3A-associated protein, 30kDa
Protein Entry	SAP30_HUMAN
UniProt ID	O75446
Species	Human

Comments

Comment type	Description
Function	Involved in the functional recruitment of the Sin3- histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N- CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. {ECO:0000250\|UniProtKB:O88574, ECO:0000269\|PubMed:9651585}.
Similarity	Belongs to the SAP30 family. {ECO:0000305}.
Subcellular Location	Nucleus.
Subunit	Interacts with SIN3A, SIN3B, HDAC2 and NCOR1. Interacts with SAMS1 (By similarity). Component of the histone deacetylase complex that includes at least SIN3A, HDAC1 and HDAC2. Interacts with HDAC1 and HCFC1. {ECO:0000250, ECO:0000269\|PubMed:12670868, ECO:0000269\|PubMed:9651585}.
Tissue Specificity	Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and thymus; lowest levels in brain, placenta, lung and kidney. {ECO:0000269\|PubMed:9702189}.