MGP Database

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MGP003704

UniProt Annotations

Entry Information
Gene Nameinositol polyphosphate-4-phosphatase, type II, 105kDa
Protein EntryINP4B_HUMAN
UniProt IDO15327
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15327-1; Sequence=Displayed; Name=2; Synonyms=stubby; IsoId=O15327-2; Sequence=VSP_047696, VSP_047697;
Catalytic Activity1-phosphatidyl-myo-inositol 3,4-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
Enzyme RegulationStrongly inhibited by inositol hexakisphosphate. {ECO:0000250}.
FunctionCatalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate.
PathwaySignal transduction; phosphatidylinositol signaling pathway.
Sequence CautionSequence=AAH72447.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
SimilarityBelongs to the inositol 3,4-bisphosphate 4-phosphatase family. {ECO:0000305}.
SimilarityContains 1 C2 domain. {ECO:0000305}.
Tissue SpecificityWidely expressed with highest levels occurring in the skeletal muscle and heart. {ECO:0000269|PubMed:9295334}.
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