MGP Database

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MGP003726

Ontology/Pathway Information

Entrez Gene ID8874
Gene NameRho guanine nucleotide exchange factor (GEF) 7
Gene Symbol ARHGEF7
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005938 IEA:UniProtKB-SubCellCcell cortex
GO:0005829 TAS:ReactomeCcytosol
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0030027 ISS:UniProtKBClamellipodium
GO:0043025 IDA:BHF-UCLCneuronal cell body
GO:0043005 IDA:BHF-UCLCneuron projection
GO:0043234 IDA:UniProtKBCprotein complex
GO:0001726 IEA:UniProtKB-SubCellCruffle
GO:0005085 IDA:BHF-UCLFguanyl-nucleotide exchange factor activity
GO:0019901 IPI:BHF-UCLFprotein kinase binding
GO:0005089 IEA:InterProFRho guanyl-nucleotide exchange factor activity
GO:0097190 TAS:ReactomePapoptotic signaling pathway
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0048041 IDA:UniProtKBPfocal adhesion assembly
GO:0002244 IEA:EnsemblPhematopoietic progenitor cell differentiation
GO:0030032 ISS:UniProtKBPlamellipodium assembly
GO:0042059 TAS:ReactomePnegative regulation of epidermal growth factor receptor signaling pathway
GO:0007399 IEA:UniProtKB-KWPnervous system development
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0043065 IMP:UniProtKBPpositive regulation of apoptotic process
GO:0010763 IDA:UniProtKBPpositive regulation of fibroblast migration
GO:0043547 IDA:BHF-UCLPpositive regulation of GTPase activity
GO:2000394 IMP:UniProtKBPpositive regulation of lamellipodium morphogenesis
GO:0032855 IMP:UniProtKBPpositive regulation of Rac GTPase activity
GO:1900026 IMP:UniProtKBPpositive regulation of substrate adhesion-dependent cell spreading
GO:0051056 TAS:ReactomePregulation of small GTPase mediated signal transduction
GO:0007165 TAS:ProtIncPsignal transduction
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_18266Axon guidance
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_111045Developmental Biology
REACT_116125Disease
REACT_12484EGFR downregulation
REACT_264068EPH-Ephrin signaling
REACT_264047Ephrin signaling
REACT_18407G alpha (12/13) signalling events
REACT_19184GPCR downstream signaling
REACT_13638NRAGE signals death through JNK
REACT_13776p75 NTR receptor-mediated signalling
REACT_11051Rho GTPase cycle
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_14797Signaling by GPCR
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_11044Signaling by Rho GTPases
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
SMP Pathway Links
SMP IDDescription
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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