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MGP003726

UniProt Annotations

Entry Information
Gene NameRho guanine nucleotide exchange factor (GEF) 7
Protein EntryARHG7_HUMAN
UniProt IDQ14155
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Name=4; IsoId=Q14155-4; Sequence=Displayed; Name=1; IsoId=Q14155-1; Sequence=VSP_011032, VSP_011035; Note=Contains a phosphoserine at position 560. Contains a phosphoserine at position 579.; Name=2; IsoId=Q14155-2; Sequence=VSP_011033; Name=3; IsoId=Q14155-3; Sequence=VSP_011034; Name=5; IsoId=Q14155-5; Sequence=VSP_034639, VSP_011035; Note=Contains a phosphoserine at position 645. Contains a phosphoserine at position 664.; Name=6; IsoId=Q14155-6; Sequence=VSP_011032;
FunctionActs as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}.
InteractionP22681:CBL; NbExp=9; IntAct=EBI-717515, EBI-518228; Q9Y2X7:GIT1; NbExp=4; IntAct=EBI-717515, EBI-466061; Q5S007:LRRK2; NbExp=6; IntAct=EBI-717515, EBI-5323863; P41227:NAA10; NbExp=3; IntAct=EBI-717515, EBI-747693; Q13153:PAK1; NbExp=7; IntAct=EBI-717515, EBI-1307; Q13177:PAK2; NbExp=4; IntAct=EBI-717515, EBI-1045887; P63000:RAC1; NbExp=8; IntAct=EBI-717515, EBI-413628; Q14160:SCRIB; NbExp=4; IntAct=EBI-717515, EBI-357345; O60880:SH2D1A; NbExp=6; IntAct=EBI-717515, EBI-6983382;
PtmPhosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by CaMK1; enhancement of GEF activity and downstream activation of RAC1. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:21406692}.
Sequence CautionSequence=AAH50521.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA09763.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD38906.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityContains 1 CH (calponin-homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00044}.
SimilarityContains 1 DH (DBL-homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00062}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Subcellular LocationCell junction, focal adhesion {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions.
SubunitInteracts with PAK kinases through the SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with PTK2/FAK1 and RAC1. Interacts with ITCH and PARVB (By similarity). Interacts with unphosphorylated PAK1. Interacts with SCRIB; interaction is direct and may play a role in regulation of apoptosis. Interacts with FRMPD4 (via N-terminus). Interacts with CaMK1. Interacts with BIN2. Isoform 1 and isoform 5 interact with SNX27. {ECO:0000250, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:19118189, ECO:0000269|PubMed:21926430, ECO:0000269|PubMed:23285027}.
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