MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003729

Record overview

MGPD IDMGP003729
Gene ID8878
SpeciesHomo sapiens (Human)
Gene Namesequestosome 1
Gene Symbol SQSTM1
Synonymsp60; p62; A170; OSIL; PDB3; ZIP3; p62B;
Alternate namessequestosome-1; EBI3-associated protein of 60 kDa; EBI3-associated protein p60; EBIAP; oxidative stress induced like; phosphotyrosine independent ligand for the Lck SH2 domain p62; phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; ubiquitin-binding protein p62;
Chromosome5
Map Location5q35
SummaryThis gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
OrthologsView orthologs and multiple alignments for SQSTM1

Proteins

sequestosome-1 isoform 1
Refseq ID:NP_003891
Protein GI:4505571
UniProt ID:Q13501
mRNA ID:NM_003900
Length:440
RefSeq Status:
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIK
EKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEM
GPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNV
EGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQ
MLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL
 
sequestosome-1 isoform 2
Refseq ID:NP_001135770
Protein GI:214830438
UniProt ID:Q13501
mRNA ID:NM_001142298
Length:356
RefSeq Status:
MAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRW
LRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSS
QPSSCCSDPSKPGGNVEGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYP
HLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL
 
sequestosome-1 isoform 2
Refseq ID:NP_001135771
Protein GI:214830451
UniProt ID:Q13501
mRNA ID:NM_001142299
Length:356
RefSeq Status:
Protein sequence is identical to GI:214830438 (mRNA isoform)
 
  logo