MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003729

Ontology/Pathway Information

Entrez Gene ID8878
Gene Namesequestosome 1
Gene Symbol SQSTM1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016235 IBA:GO_CentralCaggresome
GO:0005776 IDA:UniProtKBCautophagic vacuole
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0000932 IDA:UniProtKBCcytoplasmic mRNA processing body
GO:0031410 IEA:UniProtKB-KWCcytoplasmic vesicle
GO:0005829 TAS:UniProtKBCcytosol
GO:0005783 IEA:UniProtKB-SubCellCendoplasmic reticulum
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016234 IDA:UniProtKBCinclusion body
GO:0005770 IEA:UniProtKB-SubCellClate endosome
GO:0005764 IEA:UniProtKB-SubCellClysosome
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0016605 IDA:UniProtKBCPML body
GO:0000407 IEA:EnsemblCpre-autophagosomal structure
GO:0042802 IPI:IntActFidentical protein binding
GO:0019901 IDA:UniProtKBFprotein kinase binding
GO:0005080 IPI:UniProtKBFprotein kinase C binding
GO:0004674 NAS:UniProtKBFprotein serine/threonine kinase activity
GO:0030971 TAS:ProtIncFreceptor tyrosine kinase binding
GO:0042169 IDA:UniProtKBFSH2 domain binding
GO:0043130 IDA:UniProtKBFubiquitin binding
GO:0008270 IEA:InterProFzinc ion binding
GO:0097190 TAS:ReactomePapoptotic signaling pathway
GO:0006914 IMP:UniProtKBPautophagy
GO:0030154 IEA:UniProtKB-KWPcell differentiation
GO:0016197 TAS:UniProtKBPendosomal transport
GO:0002376 IEA:UniProtKB-KWPimmune system process
GO:0035556 TAS:UniProtKBPintracellular signal transduction
GO:0016236 ISS:UniProtKBPmacroautophagy
GO:0043066 TAS:ReactomePnegative regulation of apoptotic process
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0043065 TAS:ReactomePpositive regulation of apoptotic process
GO:0016239 IMP:UniProtKBPpositive regulation of macroautophagy
GO:0001934 IEA:EnsemblPpositive regulation of protein phosphorylation
GO:0045944 TAS:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0051291 IEA:EnsemblPprotein heterooligomerization
GO:0008104 TAS:UniProtKBPprotein localization
GO:0006468 NAS:GOCPprotein phosphorylation
GO:0043122 IMP:UniProtKBPregulation of I-kappaB kinase/NF-kappaB signaling
GO:0046578 NAS:UniProtKBPregulation of Ras protein signal transduction
GO:0006950 TAS:UniProtKBPresponse to stress
GO:0006511 TAS:ProtIncPubiquitin-dependent protein catabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_75790Cytokine Signaling in Immune system
REACT_6900Immune System
REACT_22442Interleukin-1 signaling
REACT_13696NF-kB is activated and signals survival
REACT_13643NRIF signals cell death from the nucleus
REACT_13776p75 NTR receptor-mediated signalling
REACT_13415p75NTR recruits signalling complexes
REACT_13537p75NTR signals via NF-kB
REACT_22232Signaling by Interleukins
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
  logo