MGP Database

MGP003730

Ontology/Pathway Information

Entrez Gene ID	8879
Gene Name	sphingosine-1-phosphate lyase 1
Gene Symbol	SGPL1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005783	IDA:UniProtKB	C	endoplasmic reticulum
GO:0005789	TAS:Reactome	C	endoplasmic reticulum membrane
GO:0030176	NAS:UniProtKB	C	integral component of endoplasmic reticulum membrane
GO:0016831	IEA:InterPro	F	carboxy-lyase activity
GO:0030170	IEA:InterPro	F	pyridoxal phosphate binding
GO:0008117	IDA:UniProtKB	F	sphinganine-1-phosphate aldolase activity
GO:0008209	IEA:Ensembl	P	androgen metabolic process
GO:0097190	IDA:UniProtKB	P	apoptotic signaling pathway
GO:0006672	IDA:UniProtKB	P	ceramide metabolic process
GO:0008210	IEA:Ensembl	P	estrogen metabolic process
GO:0060325	IEA:Ensembl	P	face morphogenesis
GO:0006631	IDA:UniProtKB	P	fatty acid metabolic process
GO:0010761	IEA:Ensembl	P	fibroblast migration
GO:0030097	IEA:Ensembl	P	hemopoiesis
GO:0001822	IEA:Ensembl	P	kidney development
GO:0033327	IEA:Ensembl	P	Leydig cell differentiation
GO:0001553	IEA:Ensembl	P	luteinization
GO:0060021	IEA:Ensembl	P	palate development
GO:0048008	IEA:Ensembl	P	platelet-derived growth factor receptor signaling pathway
GO:0009791	IEA:Ensembl	P	post-embryonic development
GO:0040014	IEA:Ensembl	P	regulation of multicellular organism growth
GO:0048705	IEA:Ensembl	P	skeletal system morphogenesis
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0007283	IEA:Ensembl	P	spermatogenesis
GO:0030148	TAS:Reactome	P	sphingolipid biosynthetic process
GO:0030149	IDA:UniProtKB	P	sphingolipid catabolic process
GO:0006665	TAS:Reactome	P	sphingolipid metabolic process
GO:0001570	IEA:Ensembl	P	vasculogenesis

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_111217	Metabolism
REACT_22258	Metabolism of lipids and lipoproteins
REACT_115810	Sphingolipid de novo biosynthesis
REACT_19323	Sphingolipid metabolism

SMP Pathway Links

SMP ID	Description
SMP00525	Fabry disease
SMP00349	Gaucher Disease
SMP00348	Globoid Cell Leukodystrophy
SMP00526	Krabbe disease
SMP00347	Metachromatic Leukodystrophy (MLD)
SMP00034	Sphingolipid Metabolism