MGP Database

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MGP003730

UniProt Annotations

Entry Information
Gene Namesphingosine-1-phosphate lyase 1
Protein EntrySGPL1_HUMAN
UniProt IDO95470
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=5.2 uM for sphingosine 1-phosphate {ECO:0000269|PubMed:24809814};
Catalytic ActivitySphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. {ECO:0000269|PubMed:11018465, ECO:0000269|PubMed:24809814}.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269|PubMed:24809814};
FunctionCleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. {ECO:0000269|PubMed:11018465, ECO:0000269|PubMed:14570870, ECO:0000269|PubMed:24809814}.
InteractionQ86WV6:TMEM173; NbExp=2; IntAct=EBI-1046170, EBI-2800345;
PathwayLipid metabolism; sphingolipid metabolism.
Sequence CautionSequence=BAA86566.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Single-pass type III membrane protein.
SubunitHomodimer. {ECO:0000269|PubMed:24809814}.
Tissue SpecificityFound in liver and kidney. {ECO:0000269|PubMed:11018465}.
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