MGP Database

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MGP003752

UniProt Annotations

Entry Information
Gene Namesrc kinase associated phosphoprotein 2
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
DomainThe SH3 domain interacts with FYB and PTK2B.
FunctionMay be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}.
InductionBy retinoic acid. {ECO:0000269|PubMed:11301322, ECO:0000269|PubMed:9837776}.
PtmPhosphorylated in resting platelets. Phosphorylated by FYN on Tyr-261 upon T-cell activation (Probable). Dephosphorylated on Tyr-75 by PTPN22. {ECO:0000269|PubMed:10942756, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:21719704, ECO:0000269|PubMed:9671755, ECO:0000269|PubMed:9755858, ECO:0000305}.
SimilarityBelongs to the SKAP family. {ECO:0000305}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:12893833}.
SubunitHomodimer (By similarity). Interacts with PTPNS1. Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3. May interact with actin (By similarity). Interacts with FYB, which is required for SKAP2 protein stability. Interacts with LAT, GRB2, PTK2B and PRAM1. May interact with FYN, HCK and LYN. Interacts with FASLG. {ECO:0000250, ECO:0000269|PubMed:10942756, ECO:0000269|PubMed:11301322, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:19807924, ECO:0000269|PubMed:21719704, ECO:0000269|PubMed:9671755, ECO:0000269|PubMed:9755858}.
Tissue SpecificityUbiquitously expressed. Present in platelets (at protein level). {ECO:0000269|PubMed:10942756, ECO:0000269|PubMed:9755858, ECO:0000269|PubMed:9837776}.
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