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MGP Database

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MGP003753

UniProt Annotations

Entry Information

Gene Name	WAS protein family, member 1
Protein Entry	WASF1_HUMAN
UniProt ID	Q92558
Species	Human

Comments

Comment type	Description
Domain	Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
Function	Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Interaction	P07737:PFN1; NbExp=2; IntAct=EBI-1548747, EBI-713780;
Sequence Caution	Sequence=BAA13399.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity	Belongs to the SCAR/WAVE family. {ECO:0000305}.
Similarity	Contains 1 WH2 domain. {ECO:0000255\|PROSITE- ProRule:PRU00406}.
Subcellular Location	Cytoplasm, cytoskeleton. Cell junction, synapse {ECO:0000250}. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas.
Subunit	Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex. Interacts with ABI1 (via N-terminus). {ECO:0000269\|PubMed:11130076, ECO:0000269\|PubMed:21107423}.
Tissue Specificity	Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.