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MGP003770

Record overview

MGPD IDMGP003770
Gene ID9021
SpeciesHomo sapiens (Human)
Gene Namesuppressor of cytokine signaling 3
Gene Symbol SOCS3
SynonymsCIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3;
Alternate namessuppressor of cytokine signaling 3; STAT-induced STAT inhibitor 3; cytokine-inducible SH2 protein 3;
Chromosome17
Map Location17q25.3
SummaryThis gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for SOCS3

Proteins

suppressor of cytokine signaling 3
Refseq ID:NP_003946
Protein GI:45439352
UniProt ID:O14543
mRNA ID:NM_003955
Length:225
RefSeq Status:
MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGG
SFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGH
LDSYEKVTQLPGPIREFLDQYDAPL
 
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