MGP Database

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MGP003770

Ontology/Pathway Information

Entrez Gene ID9021
Gene Namesuppressor of cytokine signaling 3
Gene Symbol SOCS3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IBA:GO_CentralCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0004860 TAS:ProtIncFprotein kinase inhibitor activity
GO:0060670 IEA:EnsemblPbranching involved in labyrinthine layer morphogenesis
GO:0019221 IBA:GO_CentralPcytokine-mediated signaling pathway
GO:0060333 TAS:ReactomePinterferon-gamma-mediated signaling pathway
GO:0007259 TAS:ProtIncPJAK-STAT cascade
GO:0060397 TAS:ReactomePJAK-STAT cascade involved in growth hormone signaling pathway
GO:0043066 TAS:ProtIncPnegative regulation of apoptotic process
GO:0046627 IBA:GO_CentralPnegative regulation of insulin receptor signaling pathway
GO:0046426 IBA:GO_CentralPnegative regulation of JAK-STAT cascade
GO:0006469 TAS:GOCPnegative regulation of protein kinase activity
GO:0060674 IEA:EnsemblPplacenta blood vessel development
GO:0045597 IEA:EnsemblPpositive regulation of cell differentiation
GO:0016567 IEA:UniProtKB-UniPathwayPprotein ubiquitination
GO:0040008 IEA:UniProtKB-KWPregulation of growth
GO:0060334 TAS:ReactomePregulation of interferon-gamma-mediated signaling pathway
GO:0060338 TAS:ReactomePregulation of type I interferon-mediated signaling pathway
GO:0060708 IEA:EnsemblPspongiotrophoblast differentiation
GO:0060707 IEA:EnsemblPtrophoblast giant cell differentiation
GO:0060337 TAS:ReactomePtype I interferon signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_75790Cytokine Signaling in Immune system
REACT_111133Growth hormone receptor signaling
REACT_6900Immune System
REACT_25162Interferon alpha/beta signaling
REACT_25078Interferon gamma signaling
REACT_25229Interferon Signaling
REACT_27307Interleukin-6 signaling
REACT_25216Regulation of IFNA signaling
REACT_24980Regulation of IFNG signaling
REACT_22232Signaling by Interleukins
REACT_169118Signaling by Leptin
REACT_111102Signal Transduction
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