MGP Database

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MGP003774

UniProt Annotations

Entry Information
Gene Namesema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Protein EntrySEM5A_HUMAN
UniProt IDQ13591
SpeciesHuman
Comments
Comment typeDescription
FunctionBifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. {ECO:0000250, ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:19850054, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}.
SimilarityBelongs to the semaphorin family. {ECO:0000305}.
SimilarityContains 1 PSI domain. {ECO:0000305}.
SimilarityContains 1 Sema domain. {ECO:0000255|PROSITE- ProRule:PRU00352}.
SimilarityContains 7 TSP type-1 domains. {ECO:0000255|PROSITE- ProRule:PRU00210}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitBinds PLXNB3.
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