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MGP003789

Record overview

MGPD IDMGP003789
Gene ID9071
SpeciesHomo sapiens (Human)
Gene Nameclaudin 10
Gene Symbol CLDN10
SynonymsOSP-L; CPETRL3;
Alternate namesclaudin-10; OSP-like protein;
Chromosome13
Map Location13q31-q34
SummaryThis gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010]
OrthologsView orthologs and multiple alignments for CLDN10

Proteins

claudin-10 isoform a
Refseq ID:NP_878268
Protein GI:33598916
UniProt ID:P78369
mRNA ID:NM_182848
Length:226
RefSeq Status:
MSRAQIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGNALGSFHCRPHFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMK
CTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRYTYNGATSVMS
SRTKYHGGEDFKTTNPSKQFDKNAYV
 
sig_peptide: 1..23
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2387
peptide sequence: 
MASTASEIIAFMVSISGWVLVSS
 
claudin-10 isoform a_i1
Refseq ID:NP_001153572
Protein GI:231569235
UniProt ID:P78369
mRNA ID:NM_001160100
Length:207
RefSeq Status:
MSRAQIWALVSGVGGFGALVAATTSNEWKVTTRASSVITATWVYQGLWMNCAGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAG
IVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQ
FDKNAYV
 
sig_peptide: 1..23
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2387
peptide sequence: 
MASTASEIIAFMVSISGWVLVSS
 
claudin-10 isoform b precursor
Refseq ID:NP_008915
Protein GI:5921465
UniProt ID:P78369
mRNA ID:NM_006984
Length:228
RefSeq Status:
MASTASEIIAFMVSISGWVLVSSTLPTDYWKVSTIDGTVITTATYWANLWKACVTDSTGVSNCKDFPSMLALDGYIQACRGLMIAAVSLGFFGSIFALFG
MKCTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRYTYNGATSV
MSSRTKYHGGEDFKTTNPSKQFDKNAYV
 
sig_peptide: 1..23
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2387
peptide sequence: 
MASTASEIIAFMVSISGWVLVSS
 
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