MGP Database

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MGP003789

UniProt Annotations

Entry Information
Gene Nameclaudin 10
Protein EntryCLD10_HUMAN
UniProt IDP78369
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Cldn10b; IsoId=P78369-1; Sequence=Displayed; Name=2; Synonyms=Cldn10a; IsoId=P78369-2; Sequence=VSP_042898; Name=3; Synonyms=Cldn10a_i1; IsoId=P78369-3; Sequence=VSP_053550; Note=Produced by alternative splicing of isoform 2.;
DomainThe fourth transmembrane region (161-181) is necessary for integration into tight junctions. {ECO:0000250}.
FunctionPlays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. May form permselective paracellular pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. Plays a key role in controlling cation selectivity and transport in the thick ascending limb (TAL) of Henle's loop in kidney. {ECO:0000269|PubMed:19383724}.
SimilarityBelongs to the claudin family. {ECO:0000305}.
Subcellular LocationCell junction, tight junction {ECO:0000269|PubMed:19383724}. Cell membrane {ECO:0000269|PubMed:19383724}; Multi-pass membrane protein {ECO:0000269|PubMed:19383724}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CLDN10ID45827ch13q32.html";
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