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MGP003790

Record overview

MGPD IDMGP003790
Gene ID9073
SpeciesHomo sapiens (Human)
Gene Nameclaudin 8
Gene Symbol CLDN8
Alternate namesclaudin-8;
Chromosome21
Map Location21q22.11
SummaryThis gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]
OrthologsView orthologs and multiple alignments for CLDN8

Proteins

claudin-8
Refseq ID:NP_955360
Protein GI:40788011
UniProt ID:P56748
mRNA ID:NM_199328
Length:225
RefSeq Status:
MATHALEIAGLFLGGVGMVGTVAVTVMPQWRVSAFIENNIVVFENFWEGLWMNCVRQANIRMQCKIYDSLLALSPDLQAARGLMCAASVMSFLAFMMAIL
GMKCTRCTGDNEKVKAHILLTAGIIFIITGMVVLIPVSWVANAIIRDFYNSIVNVAQKRELGEALYLGWTTALVLIVGGALFCCVFCCNEKSSSYRYSIP
SHRTTQKSYHTGKKSPSVYSRSQYV
 
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