MGP Database

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MGP003790

UniProt Annotations

Entry Information
Gene Nameclaudin 8
Protein EntryCLD8_HUMAN
UniProt IDP56748
SpeciesHuman
Comments
Comment typeDescription
FunctionPlays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}.
MiscellaneousA protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells. {ECO:0000305|PubMed:22042635}.
SimilarityBelongs to the claudin family. {ECO:0000305}.
Subcellular LocationCell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells.
SubunitDirectly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO- 3. {ECO:0000250}.
Tissue SpecificityExpressed in the epididymis, mainly in the caput segment. {ECO:0000269|PubMed:17287494}.
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