MGP Database

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MGP003829

UniProt Annotations

Entry Information
Gene Nameleucine rich repeat (in FLII) interacting protein 1
Protein EntryLRRF1_HUMAN
UniProt IDQ32MZ4
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q32MZ4-1; Sequence=Displayed; Name=2; IsoId=Q32MZ4-2; Sequence=VSP_020265; Name=3; IsoId=Q32MZ4-3; Sequence=VSP_020264, VSP_020265; Name=4; IsoId=Q32MZ4-4; Sequence=VSP_046809, VSP_046810, VSP_046811, VSP_046812, VSP_046813, VSP_046814;
Developmental StageWidely expressed in fetal tissues. {ECO:0000269|PubMed:9671805}.
DomainThe coiled coil mediates dimerization. {ECO:0000269|PubMed:23099021}.
DomainThe DNA-binding domain is intrinsically unstructured. {ECO:0000269|PubMed:23099021}.
FunctionTranscriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}.
InteractionQ13045:FLII; NbExp=2; IntAct=EBI-1369100, EBI-351549;
Sequence CautionSequence=AAH01385.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAY14672.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the LRRFIP family. {ECO:0000305}.
Subcellular LocationNucleus. Cytoplasm.
SubunitHomodimer. May also form higher oligomers. Interacts with FLII. Interacts with MYD88. Competes with FLII for MyD88-binding, even in the absence of LPS. {ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:23099021, ECO:0000269|PubMed:9671805}.
Tissue SpecificityUbiquitously expressed. {ECO:0000269|PubMed:9671805, ECO:0000269|PubMed:9705290}.
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