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MGP003835

Record overview

MGPD IDMGP003835
Gene ID9232
SpeciesHomo sapiens (Human)
Gene Namepituitary tumor-transforming 1
Gene Symbol PTTG1
SynonymsEAP1; PTTG; HPTTG; TUTR1;
Alternate namessecurin; ESP1-associated protein 1; pituitary tumor-transforming gene 1 protein; tumor-transforming protein 1;
Chromosome5
Map Location5q35.1
SummaryThe encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
OrthologsView orthologs and multiple alignments for PTTG1

Proteins

securin
Refseq ID:NP_004210
Protein GI:4758980
UniProt ID:O95997
mRNA ID:NM_004219
Length:202
RefSeq Status:
MATLIYVDKENGEPGTRVVAKDGLKLGSGPSIKALDGRSQVSTPRFGKTFDAPPALPKATRKALGTVNRATEKSVKTKGPLKQKQPSFSAKKMTEKTVKA
KSSVPASDDAYPEIEKFFPFNPLDFESFDLPEEHQIAHLPLSGVPLMILDEERELEKLFQLGPPSPVKMPSPPWESNLLQSPSSILSTLDVELPPVCCDI
DI
 
securin
Refseq ID:NP_001269312
Protein GI:538260594
UniProt ID:O95997
mRNA ID:NM_001282383
Length:202
RefSeq Status:
Protein sequence is identical to GI:4758980 (mRNA isoform)
 
securin
Refseq ID:NP_001269311
Protein GI:538260592
UniProt ID:O95997
mRNA ID:NM_001282382
Length:202
RefSeq Status:
Protein sequence is identical to GI:4758980 (mRNA isoform)
 
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