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MGP003839

UniProt Annotations

Entry Information
Gene Namedehydrogenase/reductase (SDR family) member 3
Protein EntryDHRS3_HUMAN
UniProt IDO75911
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75911-1; Sequence=Displayed; Name=2; IsoId=O75911-2; Sequence=VSP_013256, VSP_013257; Note=No experimental confirmation available.;
Catalytic ActivityAll-trans-retinol + NADP(+) = all-trans- retinal + NADPH.
FunctionCatalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH. {ECO:0000269|PubMed:9705317}.
InductionBy retinoic acid. {ECO:0000269|PubMed:11861404}.
MiscellaneousLocated in a region of chromosome 1 which is often deleted in aggressive neuroblastoma tumors.
Sequence CautionSequence=AAQ88460.1; Type=Frameshift; Positions=15; Evidence={ECO:0000305};
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityWidely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments. {ECO:0000269|PubMed:11861404, ECO:0000269|PubMed:9705317}.
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