MGP Database

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MGP003840

Ontology/Pathway Information

Entrez Gene ID9252
Gene Nameribosomal protein S6 kinase, 90kDa, polypeptide 5
Gene Symbol RPS6KA5
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005524 IDA:UniProtKBFATP binding
GO:0000287 IEA:InterProFmagnesium ion binding
GO:0004672 IDA:UniProtKBFprotein kinase activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0007411 TAS:ReactomePaxon guidance
GO:0007173 TAS:UniProtKBPepidermal growth factor receptor signaling pathway
GO:0043990 IDA:UniProtKBPhistone H2A-S1 phosphorylation
GO:0043987 IMP:UniProtKBPhistone H3-S10 phosphorylation
GO:0043988 IMP:UniProtKBPhistone H3-S28 phosphorylation
GO:0016572 IDA:UniProtKBPhistone phosphorylation
GO:0006954 IEA:UniProtKB-KWPinflammatory response
GO:0045087 TAS:ReactomePinnate immune response
GO:0070498 IMP:BHF-UCLPinterleukin-1-mediated signaling pathway
GO:0035556 IDA:UniProtKBPintracellular signal transduction
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0001818 TAS:UniProtKBPnegative regulation of cytokine production
GO:0045892 IDA:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0032793 TAS:UniProtKBPpositive regulation of CREB transcription factor activity
GO:0035066 IMP:BHF-UCLPpositive regulation of histone acetylation
GO:0033129 IMP:BHF-UCLPpositive regulation of histone phosphorylation
GO:0051092 IMP:UniProtKBPpositive regulation of NF-kappaB transcription factor activity
GO:0045944 IMP:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0006355 IDA:UniProtKBPregulation of transcription, DNA-templated
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_18266Axon guidance
REACT_12524CREB phosphorylation
REACT_111045Developmental Biology
REACT_12599ERK/MAPK targets
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_22205L1CAM interactions
REACT_21308MAP kinase activation in TLR cascade
REACT_21328MAPK targets/ Nuclear events mediated by MAP kinases
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_18334NCAM signaling for neurite out-growth
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12433Nuclear Events (kinase and transcription factor activation)
REACT_22365Recycling pathway of L1
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
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