MGP Database

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MGP003874

Ontology/Pathway Information

Entrez Gene ID9353
Gene Nameslit homolog 2 (Drosophila)
Gene Symbol SLIT2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IDA:UniProtKBCcell surface
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016020 NAS:UniProtKBCmembrane
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005509 NAS:UniProtKBFcalcium ion binding
GO:0045499 IEA:EnsemblFchemorepellent activity
GO:0005095 IDA:UniProtKBFGTPase inhibitor activity
GO:0008201 IDA:UniProtKBFheparin binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0043237 IDA:UniProtKBFlaminin-1 binding
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0043394 IPI:UniProtKBFproteoglycan binding
GO:0048495 IPI:UniProtKBFRoundabout binding
GO:0061364 IEP:UniProtKBPapoptotic process involved in luteolysis
GO:0048846 IDA:UniProtKBPaxon extension involved in axon guidance
GO:0007411 IDA:UniProtKBPaxon guidance
GO:0048754 IDA:UniProtKBPbranching morphogenesis of an epithelial tube
GO:0002042 IMP:BHF-UCLPcell migration involved in sprouting angiogenesis
GO:0071504 IDA:UniProtKBPcellular response to heparin
GO:0032870 IEP:UniProtKBPcellular response to hormone stimulus
GO:0021836 IDA:UniProtKBPchemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0021972 IMP:BHF-UCLPcorticospinal neuron axon guidance through spinal cord
GO:0033563 IEA:EnsemblPdorsal/ventral axon guidance
GO:0050929 IDA:UniProtKBPinduction of negative chemotaxis
GO:0001701 IEA:EnsemblPin utero embryonic development
GO:0060763 IEA:EnsemblPmammary duct terminal end bud growth
GO:0001656 IEA:EnsemblPmetanephros development
GO:0008045 IDA:UniProtKBPmotor neuron axon guidance
GO:0050919 IDA:UniProtKBPnegative chemotaxis
GO:0030837 IDA:UniProtKBPnegative regulation of actin filament polymerization
GO:0030517 IEA:EnsemblPnegative regulation of axon extension
GO:0043086 IDA:GOCPnegative regulation of catalytic activity
GO:0030308 IMP:BHF-UCLPnegative regulation of cell growth
GO:0030336 IDA:UniProtKBPnegative regulation of cell migration
GO:0008285 IEA:EnsemblPnegative regulation of cell proliferation
GO:0090288 IDA:BHF-UCLPnegative regulation of cellular response to growth factor stimulus
GO:0070100 IMP:BHF-UCLPnegative regulation of chemokine-mediated signaling pathway
GO:0010596 IDA:UniProtKBPnegative regulation of endothelial cell migration
GO:0010629 IEA:EnsemblPnegative regulation of gene expression
GO:0010593 IDA:UniProtKBPnegative regulation of lamellipodium assembly
GO:0002689 IDA:UniProtKBPnegative regulation of leukocyte chemotaxis
GO:0090027 ISS:BHF-UCLPnegative regulation of monocyte chemotaxis
GO:0071676 IDA:BHF-UCLPnegative regulation of mononuclear cell migration
GO:0090024 IDA:UniProtKBPnegative regulation of neutrophil chemotaxis
GO:0001933 IDA:UniProtKBPnegative regulation of protein phosphorylation
GO:0090260 IDA:UniProtKBPnegative regulation of retinal ganglion cell axon guidance
GO:0051058 IDA:UniProtKBPnegative regulation of small GTPase mediated signal transduction
GO:0071672 IDA:BHF-UCLPnegative regulation of smooth muscle cell chemotaxis
GO:0014912 IDA:BHF-UCLPnegative regulation of smooth muscle cell migration
GO:0043116 IDA:UniProtKBPnegative regulation of vascular permeability
GO:0043065 IMP:UniProtKBPpositive regulation of apoptotic process
GO:0050772 TAS:UniProtKBPpositive regulation of axonogenesis
GO:0051414 IEP:UniProtKBPresponse to cortisol
GO:0031290 IDA:UniProtKBPretinal ganglion cell axon guidance
GO:0035385 IMP:BHF-UCLPRoundabout signaling pathway
GO:0016337 IEA:EnsemblPsingle organismal cell-cell adhesion
GO:0001657 IMP:UniProtKBPureteric bud development
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_19226Activation of Rac
REACT_18266Axon guidance
REACT_111045Developmental Biology
REACT_19342Inactivation of Cdc42 and Rac
REACT_22237Netrin-1 signaling
REACT_19376Regulation of Commissural axon pathfinding by Slit and Robo
REACT_19230Role of Abl in Robo-Slit signaling
REACT_19351Signaling by Robo receptor
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