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MGP003874

UniProt Annotations

Entry Information

Gene Name	slit homolog 2 (Drosophila)
Protein Entry	SLIT2_HUMAN
UniProt ID	O94813
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1 {ECO:0000305}; IsoId=O94813-1; Sequence=Displayed; Name=2 {ECO:0000305}; IsoId=O94813-2; Sequence=VSP_050035, VSP_050036; Name=3 {ECO:0000305}; IsoId=O94813-3; Sequence=VSP_050036;
Domain	The leucine-rich repeat domain is sufficient for guiding both axon projection and neuronal migration, in vitro. {ECO:0000269\|PubMed:11222645}.
Function	Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth- stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post- crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration. {ECO:0000269\|PubMed:10102268, ECO:0000269\|PubMed:10864954, ECO:0000269\|PubMed:10975526, ECO:0000269\|PubMed:11239147, ECO:0000269\|PubMed:11309622, ECO:0000269\|PubMed:11404413}.
Interaction	Self; NbExp=2; IntAct=EBI-1236865, EBI-1236865;
Similarity	Contains 1 CTCK (C-terminal cystine knot-like) domain. {ECO:0000255\|PROSITE-ProRule:PRU00039}.
Similarity	Contains 1 laminin G-like domain. {ECO:0000255\|PROSITE-ProRule:PRU00122}.
Similarity	Contains 20 LRR (leucine-rich) repeats. {ECO:0000305}.
Similarity	Contains 4 LRRCT domains. {ECO:0000305}.
Similarity	Contains 4 LRRNT domains. {ECO:0000305}.
Similarity	Contains 7 EGF-like domains. {ECO:0000255\|PROSITE- ProRule:PRU00076, ECO:0000305}.
Subcellular Location	Secreted {ECO:0000269\|PubMed:10102268}. Note=The C-terminal cleavage protein is more diffusible than the larger N-terminal protein that is more tightly cell associated.
Subunit	Interacts with GREM1 (By similarity). Homodimer. Binds ROBO1 and ROBO2 with high affinity. {ECO:0000250, ECO:0000269\|PubMed:10102268, ECO:0000269\|PubMed:11404413, ECO:0000269\|PubMed:17848514, ECO:0000269\|PubMed:19498462}.
Tissue Specificity	Fetal lung and kidney, and adult spinal cord. Weak expression in adult adrenal gland, thyroid, trachea and other tissues examined. {ECO:0000269\|PubMed:10349621, ECO:0000269\|PubMed:9813312}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/SLIT2ID42328ch4p15.html";