MGP Database

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MGP003879

UniProt Annotations

Entry Information
Gene Namesolute carrier family 22 (organic anion transporter), member 8
Protein EntryS22A8_HUMAN
UniProt IDQ8TCC7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8TCC7-1; Sequence=Displayed; Name=2; IsoId=Q8TCC7-2; Sequence=VSP_022565; Note=No experimental confirmation available.; Name=5; IsoId=Q8TCC7-5; Sequence=VSP_045824; Note=No experimental confirmation available.; Name=3; IsoId=Q8TCC7-3; Sequence=VSP_022562, VSP_022563, VSP_022564; Note=No experimental confirmation available.; Name=4; IsoId=Q8TCC7-4; Sequence=VSP_045272; Note=No experimental confirmation available.;
FunctionPlays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA). {ECO:0000269|PubMed:14586168, ECO:0000269|PubMed:15644426, ECO:0000269|PubMed:15846473, ECO:0000269|PubMed:16455804}.
Sequence CautionSequence=AAD19357.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BAD92929.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
Subcellular LocationBasolateral cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity). {ECO:0000250}.
Tissue SpecificityExpressed in kidney. {ECO:0000269|PubMed:11912245}.
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