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MGP003911

Record overview

MGPD IDMGP003911
Gene ID9453
SpeciesHomo sapiens (Human)
Gene Namegeranylgeranyl diphosphate synthase 1
Gene Symbol GGPS1
SynonymsGGPPS; GGPPS1;
Alternate namesgeranylgeranyl pyrophosphate synthase; (2E,6E)-farnesyl diphosphate synthase; GGPP synthase; GGPPSase; dimethylallyltranstransferase; farnesyl diphosphate synthase; farnesyltranstransferase; geranyltranstransferase;
Chromosome1
Map Location1q43
EC Number2.5.1.-
SummaryThis gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
OrthologsView orthologs and multiple alignments for GGPS1

Proteins

geranylgeranyl pyrophosphate synthase
Refseq ID:NP_001032354
Protein GI:83700220
UniProt ID:O95749
mRNA ID:NM_001037277
Length:300
RefSeq Status:
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGL
EKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSE
NKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
 
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