MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003911

UniProt Annotations

Entry Information
Gene Namegeranylgeranyl diphosphate synthase 1
Protein EntryGGPPS_HUMAN
UniProt IDO95749
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95749-1; Sequence=Displayed; Name=2; IsoId=O95749-2; Sequence=VSP_056578; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=3 uM for isopentenyl diphosphate {ECO:0000269|PubMed:16698791}; KM=4.2 uM for farnesyl diphosphate {ECO:0000269|PubMed:16698791};
Catalytic Activity(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. {ECO:0000269|PubMed:16698791}.
Catalytic ActivityDimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. {ECO:0000269|PubMed:16698791}.
Catalytic ActivityGeranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate. {ECO:0000269|PubMed:16698791}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305}; Note=Binds 3 Mg(2+) ions. {ECO:0000305};
Enzyme RegulationSubject to product inhibition by geranylgeranyl diphosphate. {ECO:0000269|PubMed:16698791}.
FunctionCatalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
PathwayIsoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
PathwayIsoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
PathwayIsoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.
SimilarityBelongs to the FPP/GGPP synthase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomohexamer; trimer of homodimers. {ECO:0000269|PubMed:16698791}.
Tissue SpecificityAbundantly expressed in testis. Found in other tissues to a lower extent.
  logo