MGP Database

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MGP003922

UniProt Annotations

Entry Information
Gene Nameproteasome (prosome, macropain) inhibitor subunit 1 (PI31)
Protein EntryPSMF1_HUMAN
UniProt IDQ92530
SpeciesHuman
Comments
Comment typeDescription
FunctionPlays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. {ECO:0000269|PubMed:10764772}.
InteractionQ9NWB1:RBFOX1; NbExp=2; IntAct=EBI-945916, EBI-945906;
SimilarityBelongs to the proteasome inhibitor PI31 family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:18495667}. Endoplasmic reticulum {ECO:0000269|PubMed:18495667}.
SubunitMonomer and homodimer. Interacts with FBXO7. Interacts with the 20S proteasome. {ECO:0000269|PubMed:10764772, ECO:0000269|PubMed:18495667}.
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