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MGP003953

UniProt Annotations

Entry Information
Gene Nameperoxiredoxin 6
Protein EntryPRDX6_HUMAN
UniProt IDP30041
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
Catalytic Activity2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
FunctionInvolved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
InteractionP29991:- (xeno); NbExp=3; IntAct=EBI-2255129, EBI-8826747; P09211:GSTP1; NbExp=2; IntAct=EBI-2255129, EBI-353467;
MiscellaneousIrreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress.
MiscellaneousThe active site is the redox-active Cys-47 oxidized to Cys-SOH. Unlike 2-Cys peroxiredoxins, PRDX6 conserves only this peroxidatic cysteine. To regenerate and activate the enzyme, the oxidized form is directly reduced to cysteine by glutathione and not thioredoxin.
SimilarityBelongs to the AhpC/TSA family. Rehydrin subfamily. {ECO:0000305}.
SimilarityContains 1 thioredoxin domain. {ECO:0000255|PROSITE- ProRule:PRU00691}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:16186110, ECO:0000269|PubMed:19188445}. Lysosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Also found in lung secretory organelles. {ECO:0000250}.
SubunitHomotetramer. Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration. May interact with HTR2A (By similarity). Interacts with APEX1 and STH. May interact with FAM168B. {ECO:0000250, ECO:0000269|PubMed:16186110, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20716133}.
Web ResourceName=NIEHS SNPs; URL="http://egp.gs.washington.edu/data/prdx6/";
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