MGP Database

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MGP003956

Ontology/Pathway Information

Entrez Gene ID9612
Gene Namenuclear receptor corepressor 2
Gene Symbol NCOR2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016020 IDA:UniProtKBCmembrane
GO:0016604 IDA:MGICnuclear body
GO:0016363 IDA:UniProtKBCnuclear matrix
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:MGICnucleus
GO:0017053 IDA:BHF-UCLCtranscriptional repressor complex
GO:0003682 IEA:InterProFchromatin binding
GO:0003677 IEA:UniProtKB-KWFDNA binding
GO:0042826 IPI:UniProtKBFhistone deacetylase binding
GO:0005112 IPI:UniProtKBFNotch binding
GO:0047485 IPI:UniProtKBFprotein N-terminus binding
GO:0003714 IMP:UniProtKBFtranscription corepressor activity
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0010467 TAS:ReactomePgene expression
GO:0000122 IDA:MGIPnegative regulation of transcription from RNA polymerase II promoter
GO:0007219 TAS:ReactomePNotch signaling pathway
GO:0072365 IMP:BHF-UCLPregulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006351 TAS:ReactomePtranscription, DNA-templated
GO:0006367 TAS:ReactomePtranscription initiation from RNA polymerase II promoter
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264165Chromatin modifying enzymes
REACT_264155Chromatin organization
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_111045Developmental Biology
REACT_116125Disease
REACT_121111Downregulation of SMAD2/3:SMAD4 transcriptional activity
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_263923HDACs deacetylate histones
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_118780NOTCH1 Intracellular Domain Regulates Transcription
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_299Signaling by NOTCH
REACT_118859Signaling by NOTCH1
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
REACT_27161Transcriptional regulation of white adipocyte differentiation
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