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MGP003956

UniProt Annotations

Entry Information
Gene Namenuclear receptor corepressor 2
Protein EntryNCOR2_HUMAN
UniProt IDQ9Y618
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; Synonyms=SMRT-alpha, TRAC-2; IsoId=Q9Y618-1; Sequence=Displayed; Name=2; Synonyms=TRAC-1; IsoId=Q9Y618-2; Sequence=VSP_003412, VSP_003413; Note=Contains only the C-terminal receptor-interacting domain and acts as an antirepressor.; Name=3; Synonyms=h-SMRT; IsoId=Q9Y618-3; Sequence=VSP_036596; Name=4; Synonyms=SMRTe; IsoId=Q9Y618-4; Sequence=VSP_036595; Name=5; Synonyms=SMRT-tau; IsoId=Q9Y618-5; Sequence=VSP_036595, VSP_003413;
DomainThe N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor- interacting domains that are divided in two separate interaction domains (ID1 and ID2).
DomainThe two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.
FunctionTranscriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. {ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:23911289}.
InductionRegulated during cell cycle progression.
InteractionP35869:AHR; NbExp=2; IntAct=EBI-80830, EBI-80780; P27540:ARNT; NbExp=2; IntAct=EBI-80830, EBI-80809; Q01094:E2F1; NbExp=2; IntAct=EBI-80830, EBI-448924; Q13547:HDAC1; NbExp=2; IntAct=EBI-80830, EBI-301834; Q15156:PML-RAR; NbExp=2; IntAct=EBI-80830, EBI-867256; Q06330:RBPJ; NbExp=3; IntAct=EBI-80830, EBI-632552; Q13573:SNW1; NbExp=4; IntAct=EBI-80830, EBI-632715;
Sequence CautionSequence=AAB91452.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAC50236.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAD20946.1; Type=Frameshift; Positions=787, 794; Evidence={ECO:0000305}; Sequence=BAD92326.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the N-CoR nuclear receptor corepressors family. {ECO:0000305}.
SimilarityContains 2 SANT domains. {ECO:0000255|PROSITE- ProRule:PRU00624}.
Subcellular LocationNucleus.
SubunitForms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SMRT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Interacts with HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1. Interacts with RXRA. {ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:11533236, ECO:0000269|PubMed:11739383, ECO:0000269|PubMed:12554770, ECO:0000269|PubMed:14690607, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:16121196, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:19786558, ECO:0000269|PubMed:20543827, ECO:0000269|PubMed:23372760, ECO:0000269|PubMed:23911289}.
Tissue SpecificityUbiquitous. High levels of expression are detected in lung, spleen and brain.
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