MGP Database

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MGP003957

UniProt Annotations

Entry Information
Gene Nameguanine deaminase
Protein EntryGUAD_HUMAN
UniProt IDQ9Y2T3
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y2T3-1; Sequence=Displayed; Name=2; Synonyms=c; IsoId=Q9Y2T3-2; Sequence=VSP_042075; Name=3; Synonyms=a; IsoId=Q9Y2T3-3; Sequence=VSP_042076;
Catalytic ActivityGuanine + H(2)O = xanthine + NH(3).
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
FunctionCatalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. {ECO:0000250}.
PathwayPurine metabolism; guanine degradation; xanthine from guanine: step 1/1.
Sequence CautionSequence=BAA86572.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the ATZ/TRZ family. {ECO:0000305}.
SubunitHomodimer. {ECO:0000269|Ref.10}.
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