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MGP003965

Record overview

MGPD IDMGP003965
Gene ID9636
SpeciesHomo sapiens (Human)
Gene NameISG15 ubiquitin-like modifier
Gene Symbol ISG15
SynonymsG1P2; IP17; UCRP; IFI15; IMD38; hUCRP;
Alternate namesubiquitin-like protein ISG15; interferon, alpha-inducible protein (clone IFI-15K); interferon-induced 17-kDa/15-kDa protein; interferon-stimulated protein, 15 kDa; ubiquitin cross-reactive protein;
Chromosome1
Map Location1p36.33
SummaryThe protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]
OrthologsView orthologs and multiple alignments for ISG15

Proteins

ubiquitin-like protein ISG15 precursor
Refseq ID:NP_005092
Protein GI:4826774
UniProt ID:P05161
mRNA ID:NM_005101
Length:165
RefSeq Status:
MGWDLTVKMLAGNEFQVSLSSSMSVSELKAQITQKIGVHAFQQRLAVHPSGVALQDRVPLASQGLGPGSTVLLVVDKCDEPLSILVRNNKGRSSTYEVRL
TQTVAHLKQQVSGLEGVQDDLFWLTFEGKPLEDQLPLGEYGLKPLSTVFMNLRLRGGGTEPGGRS
 
mat_peptide: 2..157
product: Ubiquitin-like protein ISG15
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P05161.5)
calculated_mol_wt: 17015
peptide sequence: 
GWDLTVKMLAGNEFQVSLSSSMSVSELKAQITQKIGVHAFQQRLAVHPSGVALQDRVPLASQGLGPGSTVLLVVDKCDEPLSILVRNNKGRSSTYEVRLT
QTVAHLKQQVSGLEGVQDDLFWLTFEGKPLEDQLPLGEYGLKPLSTVFMNLRLRGG
 
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