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MGP003969

Record overview

MGPD IDMGP003969
Gene ID9653
SpeciesHomo sapiens (Human)
Gene Nameheparan sulfate 2-O-sulfotransferase 1
Gene Symbol HS2ST1
SynonymsdJ604K5.2;
Alternate namesheparan sulfate 2-O-sulfotransferase 1; 2-O-sulfotransferase; 2OST;
Chromosome1
Map Location1p22.3
EC Number2.8.2.-;
SummaryHeparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008]
OrthologsView orthologs and multiple alignments for HS2ST1

Proteins

heparan sulfate 2-O-sulfotransferase 1 isoform 1
Refseq ID:NP_036394
Protein GI:6912420
UniProt ID:Q7LGA3
mRNA ID:NM_012262
Length:356
RefSeq Status:
MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRSKLERAIARHEVREIEQRHTMDGPRQDATLDEEEDMVIIYNRVPKTASTSFTNIAYDLCAKN
KYHVLHINTTKNNPVMSLQDQVRFVKNITSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKKTFDE
CVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQAKYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATELYRTGKKSHLRKTTEKKLPTKQT
IAKLQQSDIWKMENEFYEFALEQFQFIRAHAVREKDGDLYILAQNFFYEKIYPKSN
 
heparan sulfate 2-O-sulfotransferase 1 isoform 2
Refseq ID:NP_001127964
Protein GI:197382758
UniProt ID:Q7LGA3
mRNA ID:NM_001134492
Length:229
RefSeq Status:
MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRSKLERAIARHEVREIEQRHTMDGPRQDATLDEEEDMVIIYNRVPKTASTSFTNIAYDLCAKN
KYHVLHINTTKNNPVMSLQDQVRFVKNITSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKKTFDE
CVAEGGSDCAPEKLWLQIPFFCGHSSECW
 
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