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MGP003969

UniProt Annotations

Entry Information
Gene Nameheparan sulfate 2-O-sulfotransferase 1
Protein EntryHS2ST_HUMAN
UniProt IDQ7LGA3
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7LGA3-1; Sequence=Displayed; Name=2; IsoId=Q7LGA3-2; Sequence=VSP_014062, VSP_014064; Note=No experimental confirmation available.; Name=3; IsoId=Q7LGA3-3; Sequence=VSP_014063; Note=No experimental confirmation available.;
FunctionCatalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). {ECO:0000250}.
PtmN-glycosylated. {ECO:0000250}.
Sequence CautionSequence=BAA32293.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the sulfotransferase 3 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
SubunitHomotrimer. Interacts with the C5-epimerase GLCE (By similarity). {ECO:0000250}.
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