MGP Database

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MGP003984

Ontology/Pathway Information

Entrez Gene ID9695
Gene NameER degradation enhancer, mannosidase alpha-like 1
Gene Symbol EDEM1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0030176 ISS:UniProtKBCintegral component of endoplasmic reticulum membrane
GO:0005509 IEA:InterProFcalcium ion binding
GO:0051787 IDA:UniProtKBFmisfolded protein binding
GO:0006987 TAS:ReactomePactivation of signaling protein activity involved in unfolded protein response
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0030968 TAS:ReactomePendoplasmic reticulum unfolded protein response
GO:0030433 ISS:UniProtKBPER-associated ubiquitin-dependent protein catabolic process
GO:0043687 TAS:ReactomePpost-translational protein modification
GO:0006457 TAS:ReactomePprotein folding
GO:0018279 TAS:ReactomePprotein N-linked glycosylation via asparagine
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_22426Asparagine N-linked glycosylation
REACT_23810Calnexin/calreticulin cycle
REACT_268132Defective ALG11 causes ALG11-CDG (CDG-1p)
REACT_267773Defective ALG12 causes ALG12-CDG (CDG-1g)
REACT_268645Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
REACT_268144Defective ALG1 causes ALG1-CDG (CDG-1k)
REACT_268833Defective ALG2 causes ALG2-CDG (CDG-1i)
REACT_268185Defective ALG3 causes ALG3-CDG (CDG-1d)
REACT_267765Defective ALG6 causes ALG6-CDG (CDG-1c)
REACT_268459Defective ALG8 causes ALG8-CDG (CDG-1h)
REACT_268015Defective ALG9 causes ALG9-CDG (CDG-1l)
REACT_268438Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
REACT_268849Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
REACT_268813Defective MAN1B1 causes MRT15
REACT_268600Defective MGAT2 causes MGAT2-CDG (CDG-2a)
REACT_267905Defective MOGS causes MOGS-CDG (CDG-2b)
REACT_268619Defective MPDU1 causes MPDU1-CDG (CDG-1f)
REACT_268458Defective RFT1 causes RFT1-CDG (CDG-1n)
REACT_116125Disease
REACT_267875Diseases associated with N-glycosylation of proteins
REACT_268324Diseases of glycosylation
REACT_25091ER Quality Control Compartment (ERQC)
REACT_18368IRE1alpha activates chaperones
REACT_17015Metabolism of proteins
REACT_23878N-glycan trimming in the ER and Calnexin/Calreticulin cycle
REACT_22161Post-translational protein modification
REACT_18356Unfolded Protein Response (UPR)
REACT_18273XBP1(S) activates chaperone genes
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