MGP Database

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MGP003984

UniProt Annotations

Entry Information
Gene NameER degradation enhancer, mannosidase alpha-like 1
Protein EntryEDEM1_HUMAN
UniProt IDQ92611
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92611-1; Sequence=Displayed; Name=2; IsoId=Q92611-2; Sequence=VSP_056703, VSP_056704; Note=No experimental confirmation available.;
FunctionExtracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2. {ECO:0000269|PubMed:12610306, ECO:0000269|PubMed:19524542, ECO:0000269|PubMed:19934218, ECO:0000269|PubMed:25092655}.
InteractionQ7L1Q6:BZW1; NbExp=1; IntAct=EBI-1056336, EBI-1046727;
Sequence CautionSequence=BAA13203.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the glycosyl hydrolase 47 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:19934218}; Single-pass type II membrane protein {ECO:0000269|PubMed:19934218}.
SubunitInteracts with DNAJC10 (By similarity). Interacts with DERL2 and DERL3. Binds to SEL1L. {ECO:0000250, ECO:0000269|PubMed:16449189, ECO:0000269|PubMed:19524542}.
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