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MGP004063

UniProt Annotations

Entry Information
Gene Nameheparan sulfate (glucosamine) 3-O-sulfotransferase 2
Protein EntryHS3S2_HUMAN
UniProt IDQ9Y278
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.
FunctionSulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
SimilarityBelongs to the sulfotransferase 1 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue SpecificityHighly expressed in the brain and weakly expressed in the heart, placenta, lung and skeletal muscle. {ECO:0000269|PubMed:9988767}.
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=HS3ST2";
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