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MGP004064

Record overview

MGPD IDMGP004064
Gene ID9957
SpeciesHomo sapiens (Human)
Gene Nameheparan sulfate (glucosamine) 3-O-sulfotransferase 1
Gene Symbol HS3ST1
Synonyms3OST; 3OST1;
Alternate namesheparan sulfate glucosamine 3-O-sulfotransferase 1; 3-OST-1; h3-OST-1; heparan sulfate 3-O-sulfotransferase 1; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1; heparin-glucosamine 3-O-sulfotransferase;
Chromosome4
Map Location4p16
EC Number2.8.2.23
SummaryHeparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HS3ST1

Proteins

heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor
Refseq ID:NP_005105
Protein GI:4826764
UniProt ID:O14792
mRNA ID:NM_005114
Length:307
RefSeq Status:
MAALLLGAVLLVAQPQLVPSRPAELGQQELLRKAGTLQDDVRDGVAPNGSAQQLPQTIIIGVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSHGL
GWYLSQMPFSWPHQLTVEKTPAYFTSPKVPERVYSMNPSIRLLLILRDPSERVLSDYTQVFYNHMQKHKPYPSIEEFLVRDGRLNVDYKALNRSLYHVHM
QNWLRFFPLRHIHIVDGDRLIRDPFPEIQKVERFLKLSPQINASNFYFNKTKGFYCLRDSGRDRCLHESKGRAHPQVDPKLLNKLHEYFHEPNKKFFELV
GRTFDWH
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2005
peptide sequence: 
MAALLLGAVLLVAQPQLVPS

mat_peptide: 21..307
product: heparan sulfate glucosamine 3-O-sulfotransferase 1
calculated_mol_wt: 33787
peptide sequence: 
RPAELGQQELLRKAGTLQDDVRDGVAPNGSAQQLPQTIIIGVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSHGLGWYLSQMPFSWPHQLTVEKT
PAYFTSPKVPERVYSMNPSIRLLLILRDPSERVLSDYTQVFYNHMQKHKPYPSIEEFLVRDGRLNVDYKALNRSLYHVHMQNWLRFFPLRHIHIVDGDRL
IRDPFPEIQKVERFLKLSPQINASNFYFNKTKGFYCLRDSGRDRCLHESKGRAHPQVDPKLLNKLHEYFHEPNKKFFELVGRTFDWH
 
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