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MGP004064

UniProt Annotations

Entry Information
Gene Nameheparan sulfate (glucosamine) 3-O-sulfotransferase 1
Protein EntryHS3S1_HUMAN
UniProt IDO14792
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.
FunctionSulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. {ECO:0000269|PubMed:9346953}.
SimilarityBelongs to the sulfotransferase 1 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus lumen {ECO:0000305}.
Tissue SpecificityHighly expressed in the brain and kidney and weakly expressed in the heart, lung and placenta. {ECO:0000269|PubMed:9988767}.
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=HS3ST1";
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