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MGP004137

UniProt Annotations

Entry Information
Gene Nameprotein disulfide isomerase family A, member 6
Protein EntryPDIA6_HUMAN
UniProt IDQ15084
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q15084-1; Sequence=Displayed; Name=2; IsoId=Q15084-2; Sequence=VSP_021803; Name=3; IsoId=Q15084-3; Sequence=VSP_054370; Note=No experimental confirmation available.; Name=4; IsoId=Q15084-4; Sequence=VSP_055173; Note=No experimental confirmation available.; Name=5; IsoId=Q15084-5; Sequence=VSP_055174; Note=No experimental confirmation available.;
Catalytic ActivityCatalyzes the rearrangement of -S-S- bonds in proteins. {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936}.
FunctionMay function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936}.
InteractionQ13162:PRDX4; NbExp=2; IntAct=EBI-1043087, EBI-2211957;
SimilarityBelongs to the protein disulfide isomerase family. {ECO:0000305}.
SimilarityContains 2 thioredoxin domains. {ECO:0000255|PROSITE- ProRule:PRU00691}.
Subcellular LocationEndoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}. Cell membrane. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SubunitPart of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with MICA on the surface of tumor cells, leading to MICA disulfide bond reduction which is required for its release from tumor cells. Interacts with ITGB3 following platelet stimulation. {ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:17495932}.
Tissue SpecificityExpressed in platelets (at protein level). {ECO:0000269|PubMed:15466936}.
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