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MGP004138

Record overview

MGPD IDMGP004138
Gene ID10133
SpeciesHomo sapiens (Human)
Gene Nameoptineurin
Gene Symbol OPTN
SynonymsNRP; FIP2; HIP7; HYPL; ALS12; GLC1E; TFIIIA-INTP;
Alternate namesoptineurin; E3-14.7K-interacting protein; FIP-2; HIP-7; Huntingtin interacting protein L; huntingtin yeast partner L; huntingtin-interacting protein 7; huntingtin-interacting protein L; nemo-related protein; optic neuropathy-inducing protein; transcription factor IIIA-interacting protein; transcrption factor IIIA-interacting protein; tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains;
Chromosome10
Map Location10p13
SummaryThis gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for OPTN

Proteins

optineurin
Refseq ID:NP_068815
Protein GI:20149572
UniProt ID:Q96CV9
mRNA ID:NM_021980
Length:577
RefSeq Status:
MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMAL
SHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPG
PTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVE
ALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEH
NNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLL
KENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII
 
optineurin
Refseq ID:NP_001008212
Protein GI:56549107
UniProt ID:Q96CV9
mRNA ID:NM_001008211
Length:577
RefSeq Status:
Protein sequence is identical to GI:20149572 (mRNA isoform)
 
optineurin
Refseq ID:NP_001008213
Protein GI:56549109
UniProt ID:Q96CV9
mRNA ID:NM_001008212
Length:577
RefSeq Status:
Protein sequence is identical to GI:20149572 (mRNA isoform)
 
optineurin
Refseq ID:NP_001008214
Protein GI:56549111
UniProt ID:Q96CV9
mRNA ID:NM_001008213
Length:577
RefSeq Status:
Protein sequence is identical to GI:20149572 (mRNA isoform)
 
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