MGP Database

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MGP004140

Ontology/Pathway Information

Entrez Gene ID10135
Gene Namenicotinamide phosphoribosyltransferase
Gene Symbol NAMPT
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005615 IEA:UniProtKB-KWCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005634 IEA:UniProtKB-SubCellCnucleus
GO:0005125 TAS:ProtIncFcytokine activity
GO:0008144 IEA:EnsemblFdrug binding
GO:0047280 IEA:UniProtKB-ECFnicotinamide phosphoribosyltransferase activity
GO:0004514 IEA:InterProFnicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0007267 TAS:ProtIncPcell-cell signaling
GO:0032922 ISS:UniProtKBPcircadian regulation of gene expression
GO:0007565 IEA:EnsemblPfemale pregnancy
GO:0009435 IEA:UniProtKB-UniPathwayPNAD biosynthetic process
GO:0019674 TAS:ReactomePNAD metabolic process
GO:0006769 TAS:ReactomePnicotinamide metabolic process
GO:0008284 TAS:ProtIncPpositive regulation of cell proliferation
GO:0051770 IDA:BHF-UCLPpositive regulation of nitric-oxide synthase biosynthetic process
GO:0048661 IEA:EnsemblPpositive regulation of smooth muscle cell proliferation
GO:0045944 IDA:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0014070 IEA:EnsemblPresponse to organic cyclic compound
GO:0007165 TAS:ProtIncPsignal transduction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006766 TAS:ReactomePvitamin metabolic process
GO:0006767 TAS:ReactomePwater-soluble vitamin metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111118BMAL1:CLOCK,NPAS2 activates circadian gene expression
REACT_24941Circadian Clock
REACT_169280Defective AMN causes hereditary megaloblastic anemia 1
REACT_169403Defective BTD causes biotidinase deficiency
REACT_169178Defective CD320 causes methylmalonic aciduria
REACT_169132Defective CUBN causes hereditary megaloblastic anemia 1
REACT_169415Defective GIF causes intrinsic factor deficiency
REACT_169312Defective HLCS causes multiple carboxylase deficiency
REACT_169363Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
REACT_169316Defective MMAA causes methylmalonic aciduria type cblA
REACT_169318Defective MMAB causes methylmalonic aciduria type cblB
REACT_169169Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
REACT_169256Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
REACT_169149Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
REACT_169439Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
REACT_169313Defective MUT causes methylmalonic aciduria mut type
REACT_169120Defective TCN2 causes hereditary megaloblastic anemia
REACT_169238Defects in biotin (Btn) metabolism
REACT_169429Defects in cobalamin (B12) metabolism
REACT_169385Defects in vitamin and cofactor metabolism
REACT_116125Disease
REACT_111217Metabolism
REACT_11193Metabolism of vitamins and cofactors
REACT_11238Metabolism of water-soluble vitamins and cofactors
REACT_11213Nicotinamide salvaging
REACT_11088Nicotinate metabolism
SMP Pathway Links
SMP IDDescription
SMP00048Nicotinate and Nicotinamide Metabolism
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