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MGP004140

UniProt Annotations

Entry Information

Gene Name	nicotinamide phosphoribosyltransferase
Protein Entry	NAMPT_HUMAN
UniProt ID	P43490
Species	Human

Comments

Comment type	Description
Catalytic Activity	Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate.
Enzyme Regulation	Inhibited by FK866. FK866 competes for the same binding site as nicotinamide, but due to its very low dissociation rate, it is essentially an irreversible inhibitor. {ECO:0000269\|PubMed:16783377}.
Function	Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250\|UniProtKB:Q99KQ4, ECO:0000269\|PubMed:24130902}.
Interaction	P02792:FTL; NbExp=3; IntAct=EBI-2829310, EBI-713279; Q01628:IFITM3; NbExp=3; IntAct=EBI-2829310, EBI-7932862; P03886:MT-ND1; NbExp=3; IntAct=EBI-2829310, EBI-1246156;
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.
Sequence Caution	Sequence=AAQ96862.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAL24400.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity	Belongs to the NAPRTase family. {ECO:0000305}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:24130902}. Cytoplasm {ECO:0000250\|UniProtKB:Q99KQ4}. Secreted {ECO:0000269\|PubMed:21741723}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000269\|PubMed:21741723, ECO:0000269\|PubMed:24130902}.
Subunit	Homodimer. {ECO:0000269\|PubMed:16783377}.
Tissue Specificity	Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/NAMPTID43890ch7q22.html";