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MGP004184

Record overview

MGPD IDMGP004184
Gene ID10267
SpeciesHomo sapiens (Human)
Gene Namereceptor (G protein-coupled) activity modifying protein 1
Gene Symbol RAMP1
Alternate namesreceptor activity-modifying protein 1; CRLR activity-modifying protein 1; calcitonin receptor-like receptor activity modifying protein 1; calcitonin-receptor-like receptor activity-modifying protein 1; receptor (calcitonin) activity modifying protein 1; receptor activity modifying protein 1;
Chromosome2
Map Location2q36-q37.1
SummaryThe protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for RAMP1

Proteins

receptor activity-modifying protein 1 precursor
Refseq ID:NP_005846
Protein GI:5032019
UniProt ID:O60894
mRNA ID:NM_005855
Length:148
RefSeq Status:
MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRY
FRSCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQSKRTEGIV
 
sig_peptide: 1..26
calculated_mol_wt: 3049
peptide sequence: 
MARALCRLPRRGLWLLLAHHLFMTTA

mat_peptide: 27..148
product: receptor activity-modifying protein 1
calculated_mol_wt: 13957
peptide sequence: 
CQEANYGALLRELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILYPFIVVP
ITVTLLVTALVVWQSKRTEGIV
 
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