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MGP004185

UniProt Annotations

Entry Information
Gene Namereceptor (G protein-coupled) activity modifying protein 3
Protein EntryRAMP3_HUMAN
UniProt IDO60896
SpeciesHuman
Comments
Comment typeDescription
FunctionPlays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. {ECO:0000269|PubMed:23674134, ECO:0000269|PubMed:9620797}.
SimilarityBelongs to the RAMP family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.
SubunitHeterodimer of CALCRL and RAMP3 (By similarity). Interacts with GPER1. {ECO:0000250, ECO:0000269|PubMed:23674134}.
Tissue SpecificityStrongly expressed in lung, breast, immune system and fetal tissues. {ECO:0000269|PubMed:9620797}.
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