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MGP004187

Record overview

MGPD IDMGP004187
Gene ID10273
SpeciesHomo sapiens (Human)
Gene NameSTIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Gene Symbol STUB1
SynonymsCHIP; UBOX1; SCAR16; HSPABP2; NY-CO-7; SDCCAG7;
Alternate namesE3 ubiquitin-protein ligase CHIP; CLL-associated antigen KW-8; antigen NY-CO-7; carboxy terminus of Hsp70-interacting protein; heat shock protein A binding protein 2 (c-terminal); serologically defined colon cancer antigen 7;
Chromosome16
Map Location16p13.3
EC Number6.3.2.-
SummaryThis gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]
OrthologsView orthologs and multiple alignments for STUB1

Proteins

E3 ubiquitin-protein ligase CHIP isoform a
Refseq ID:NP_005852
Protein GI:56181387
UniProt ID:Q9UNE7
mRNA ID:NM_005861
Length:303
RefSeq Status:
MKGKEEKEGGARLGAGGGSPEKSPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQHEQALADCRRALELDGQSVKAHFFL
GQCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDIPSALRIAKKKRWNSIEERRIHQESELHSYLSRLIAAERERELEECQRNHEGDEDDSHVRAQQACI
EAKHDKYMADMDELFSQVDEKRKKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTRSPLTQEQLIPNLAMKEVIDAFISENGWV
EDY
 
E3 ubiquitin-protein ligase CHIP isoform b
Refseq ID:NP_001280126
Protein GI:645912990
UniProt ID:Q9UNE7
mRNA ID:NM_001293197
Length:231
RefSeq Status:
MQQHEQALADCRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDIPSALRIAKKKRWNSIEERRIHQESELHSYLSRLIAAE
RERELEECQRNHEGDEDDSHVRAQQACIEAKHDKYMADMDELFSQVDEKRKKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTR
SPLTQEQLIPNLAMKEVIDAFISENGWVEDY
 
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