MGP Database

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MGP004187

Ontology/Pathway Information

Entrez Gene ID10273
Gene NameSTIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Gene Symbol STUB1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HGNCCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005783 IDA:ParkinsonsUK-UCLCendoplasmic reticulum
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0045111 IDA:HPACintermediate filament cytoskeleton
GO:0042405 IDA:BHF-UCLCnuclear inclusion body
GO:0005654 IDA:HPACnucleoplasm
GO:0005886 IDA:HPACplasma membrane
GO:0031371 TAS:HGNCCubiquitin conjugating enzyme complex
GO:0000151 IDA:UniProtKBCubiquitin ligase complex
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0001664 IPI:ParkinsonsUK-UCLFG-protein coupled receptor binding
GO:0030544 IDA:HGNCFHsp70 protein binding
GO:0051879 IDA:BHF-UCLFHsp90 protein binding
GO:0019900 IPI:BHF-UCLFkinase binding
GO:0016874 IEA:UniProtKB-KWFligase activity
GO:0051787 IDA:BHF-UCLFmisfolded protein binding
GO:0030674 TAS:HGNCFprotein binding, bridging
GO:0042803 ISS:UniProtKBFprotein homodimerization activity
GO:0046332 IDA:HGNCFSMAD binding
GO:0030911 IDA:HGNCFTPR domain binding
GO:0061630 IDA:MGIFubiquitin protein ligase activity
GO:0031625 IPI:ParkinsonsUK-UCLFubiquitin protein ligase binding
GO:0004842 IDA:UniProtKBFubiquitin-protein transferase activity
GO:0034450 ISS:UniProtKBFubiquitin-ubiquitin ligase activity
GO:0071218 IDA:BHF-UCLPcellular response to misfolded protein
GO:0006281 IEA:UniProtKB-KWPDNA repair
GO:0006515 IDA:BHF-UCLPmisfolded or incompletely synthesized protein catabolic process
GO:0030512 TAS:ReactomePnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0090035 IDA:BHF-UCLPpositive regulation of chaperone-mediated protein complex assembly
GO:0032436 IDA:HGNCPpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398 IDA:HGNCPpositive regulation of protein ubiquitination
GO:0043161 IDA:HGNCPproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865 IDA:UniProtKBPprotein autoubiquitination
GO:0070534 IDA:UniProtKBPprotein K63-linked ubiquitination
GO:0051604 TAS:HGNCPprotein maturation
GO:0000209 IMP:UniProtKBPprotein polyubiquitination
GO:0031943 IDA:HGNCPregulation of glucocorticoid metabolic process
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
GO:0006511 IMP:UniProtKBPubiquitin-dependent protein catabolic process
GO:0030579 IDA:HGNCPubiquitin-dependent SMAD protein catabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_116125Disease
REACT_120727Downregulation of TGF-beta receptor signaling
REACT_6900Immune System
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_115755Signaling by ERBB2
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_120850TGF-beta receptor signaling activates SMADs
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
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