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MGP004205

Record overview

MGPD IDMGP004205
Gene ID10346
SpeciesHomo sapiens (Human)
Gene Nametripartite motif containing 22
Gene Symbol TRIM22
SynonymsRNF94; STAF50; GPSTAF50;
Alternate namesE3 ubiquitin-protein ligase TRIM22; 50 kDa-stimulated trans-acting factor; RING finger protein 94; staf-50; stimulated trans-acting factor (50 kDa); tripartite binding motif 22; tripartite motif protein TRIM22; tripartite motif-containing 22; tripartite motif-containing protein 22;
Chromosome11
Map Location11p15
EC Number6.3.2.-
SummaryThe protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
OrthologsView orthologs and multiple alignments for TRIM22

Proteins

E3 ubiquitin-protein ligase TRIM22 isoform 1
Refseq ID:NP_006065
Protein GI:117938316
UniProt ID:Q8IYM9
mRNA ID:NM_006074
Length:498
RefSeq Status:
MDFSVKVDIEKEVTCPICLELLTEPLSLDCGHSFCQACITAKIKESVIISRGESSCPVCQTRFQPGNLRPNRHLANIVERVKEVKMSPQEGQKRDVCEHH
GKKLQIFCKEDGKVICWVCELSQEHQGHQTFRINEVVKECQEKLQVALQRLIKEDQEAEKLEDDIRQERTAWKNYIQIERQKILKGFNEMRVILDNEEQR
ELQKLEEGEVNVLDNLAAATDQLVQQRQDASTLISDLQRRLRGSSVEMLQDVIDVMKRSESWTLKKPKSVSKKLKSVFRVPDLSGMLQVLKELTDVQYYW
VDVMLNPGSATSNVAISVDQRQVKTVRTCTFKNSNPCDFSAFGVFGCQYFSSGKYYWEVDVSGKIAWILGVHSKISSLNKRKSSGFAFDPSVNYSKVYSR
YRPQYGYWVIGLQNTCEYNAFEDSSSSDPKVLTLFMAVPPCRIGVFLDYEAGIVSFFNVTNHGALIYKFSGCRFSRPAYPYFNPWNCLVPMTVCPPSS
 
E3 ubiquitin-protein ligase TRIM22 isoform 2
Refseq ID:NP_001186502
Protein GI:313760629
UniProt ID:Q8IYM9
mRNA ID:NM_001199573
Length:494
RefSeq Status:
MDFSVKVDIEKEVTCPICLELLTEPLSLDCGHSFCQACITAKIKESVIISRGESSCPVCQTRFQPGNLRPNRHLANIVERVKEVKMSPQEGQKRDVCEHH
GKKLQIFCKEDGKVICWVCELSQEHQGHQTFRINEVVKECQEKLQVALQRLIKEDQEAEKLEDDIRQERTAWKIERQKILKGFNEMRVILDNEEQRELQK
LEEGEVNVLDNLAAATDQLVQQRQDASTLISDLQRRLRGSSVEMLQDVIDVMKRSESWTLKKPKSVSKKLKSVFRVPDLSGMLQVLKELTDVQYYWVDVM
LNPGSATSNVAISVDQRQVKTVRTCTFKNSNPCDFSAFGVFGCQYFSSGKYYWEVDVSGKIAWILGVHSKISSLNKRKSSGFAFDPSVNYSKVYSRYRPQ
YGYWVIGLQNTCEYNAFEDSSSSDPKVLTLFMAVPPCRIGVFLDYEAGIVSFFNVTNHGALIYKFSGCRFSRPAYPYFNPWNCLVPMTVCPPSS
 
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